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Reginald Halaby
Professor, Biology, College of Science and Mathematics
- Office:
- Science Hall 120
- Email:
- halabyr@montclair.edu
- Phone:
- 973-655-7982
- Degrees:
- BA, Boston University
- MPhil, The City University of New York
- PhD, The City University of New York
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博士
Specialization
Induction of lysosomal-mediated apoptosis in chemoresistant human breast and prostate cancer cells using triptolide (Thunder God Vine), a Chinese herb that has been used in traditional Chinese medicine for over two centuries. We have demonstrated that triptolide's apoptotic abilities are due, in part, to it being a lysosomotropic agent.
Resume/CV
Links
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- American Association for Cancer Research
- American Cancer Society
- American Institute for Cancer Research
- National Cancer Institute
- Boston University - Dr. Halaby's Alma Mater
- Explore my research at Research with Montclair
- Explore my research at Research with New Jersey
- Scholarship and Creative Works @ Digital Commons
Documents
- Natural Products Induce Lysosomal Membrane Permeabilization as an Anticancer Strategy
- Triptolide induces cytosolic translocation of lysosomal hydrolases andmitochondrial permeabilization in MCF-7 cells
- Lysosomes contribute to multidrug resistance in cancer cells
- Sabbatical Research using CRISPR to Knock Out FOXO3 Gene in Cancer Cells at the University of Texas Rio Grande Valley
- Immunosuppressive, Anti-inflammatory, and Anticancer Properties of Triptolide
- Role of Lysosomes in Cancer Therapy
- Triptolide Induces Lysosomal-Mediated Programmed Cell Death in MCF-7 Breast Cancer Cells
- Triptolide: Novel Anticancer Agent for Chemoresistant Cancer Cells that are Caspase-3 Deficient
- Apoptosis and Autoimmune Disorders Book Chapter
- Apoptosis and Photoreceptors
Research Projects
Targeting lysosomes in cancer as a therapeutic approach against apoptosis-resistant tumors
Cancer cells become resistant to treatment protocols by mutating their DNA sequence: inactivating pro-apoptotic and tumor suppressor genes; activating oncogenes; etc. Furthermore, most chemotherapy drugs are nonspecific, killing all rapidly dividing cells including healthy ones. Cancer cells possess larger and more active lysosomes compared to normal cells. Therefore, targeting lysosomes may lead to the design of novel, more effective anticancer drugs.
Triptolide induces apoptosis via a lysosomal mechanism
We provide evidence suggesting that triptolide disrupts the lysosomal membrane, which results in the leakage of lysosomal enzymes to the cytosol where the enzymes trigger the intrinsic apoptotic pathway.